At 15:05 it isn't clear what is meant by a "full campaign", but it does sound like you can set up games to be only one age. I hope so, as I am skeptical about swapping civilizations. It was actually the primary thing that put me off Humankind, rather than a selling point. Resetting not only your Civ's identity but also the world's resources, map size, and the tech tree is concerning. If one age isn't an option, I am sure mods will save us at least.
Mod support and multiplayer are huge interests for dedicated fans, so hopefully we will get more information soon. VI improved a lot from V, so I expect it will be good.
I prefer the new graphics to Civ VI's overall, but I don't want to say it actually tops V until I've played it myself. A few screens seemed visually unfinshed. Story events, navigable rivers, leader skill trees, and the calamities at the end of ages seem intriguing at least. No mention of a world congress, hopefully they have a better system in mind than VI's.
Still curious about culture progression. They didn't show a card system like VI, so that at least makes me hopeful. Ideally I would like a permanent unlock/upgrade tree and a way to temporarily boost something at a cost in another system, like edicts in Stellaris.
Looks like districts and wonders still take a tile to build, but now other buildings do too? Cities sprawl out a lot, and are diverse within. Perhaps we will be able to build duplicate buildings that were previously one per city, especially since they mentioned city specializations. It also seems like workers/builders might be attached to a particular city rather than movable units.
Overall, I'm a bit less excited and more worried. There were a lot of changes from V to VI that I was disappointed with from the onset and honestly they did not grow on me.