Python

Use venv/bin/python app.py to run it.

I use pipenv with pyenv together. This works pretty well, also in cron jobs. Just add pipenv run python script.py to the cron table.

As someone's new comments just brought me back to this post, I'll point out that these days there's another good option: uv run.

You could package it and install with pipx

Just in case this comment didn't make it explicitly clear, you can just invoke the python binary inside your venv directly and it will automatically locate all the libraries that are installed in your virtual environment.

To show how this works, you can look at the sys.path variable to see which paths python will search for modules when you run import statements. Try running python3 -c 'import sys; print(sys.path)' using your system python, and you will only see system python library paths. Then, try running it again after replacing python3 with the full path to the python3 binary in your venv, and you will see an additional entry in the output with the lib directory in your venv, which shows that python will also look there for modules when an import statement is executed.

Does it need access to anything local? If not, you could run it as an AWS Lambda on a schedule.