this post was submitted on 27 Jan 2024
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I often hear, "You should never cheap out on a good office chair, shoes, underpants, backpack etc.." but what are some items that you would feel OK to cheap out on?

This can by anything from items such as: expensive clothing brands to general groceries.

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[โ€“] [email protected] 8 points 9 months ago (1 children)

Caveat: you aren't super sensitive to extra/less medicine. The tolerances for generic are much wider.

[โ€“] [email protected] 8 points 9 months ago (1 children)

Technically no. The tolerances should be more or less the same (generally 90%-110% label claim for the active ingredient) . Manufacturers aim for 100% and generally hit that target (or get very close to it).

The bioavailability could be different though - if you are doing a bioequivalence trial for generic VS brand, the generic would have to be between 80% - 120%. This difference is generally a result of the starches, fillers, and other stuff that may be in a generic formulation.

Same net effect as your comment (wider tolerances), but there is a bit more nuance.

[โ€“] [email protected] 2 points 9 months ago

Extra info is great. Thanks for adding to the discussion!