No, but that's two holes. And it's because the holes are not connect by a single, unbroken cylinder. It's the material at the edge of those holes and the 90° turn at the corners that makes the holes disconnected.

That doesn't change the topology though. Or at least you can't without it no longer being a straw.

A straw is the product of a circle and an interval. Either the knot doesn't fully seal the interval, meaning it's topology is maintained, or you completely seal the straw, changing it from 1 long interval to 2 separate intervals, changing the object entirely.

In this situation, the straw would not be completely sealed. It is clearly inefficient, but technically there exists a path for which there is a level of force that could applied that would make the straw function.

Yeah, that's a concept that gets covered extensively in anatomy, immunology, and microbiology. It's called "the donut model". This is not a joke. It clearly shows how your digestive system is exposed to the outside world, similar to skin. You can obviously see why this is important immunologically, since germs can just get into the mouth/butthole in a way that they can't penetrate skin.

It's one long hole.

that is actually the case. there is an unimpeded path from your mouth to your anus

Because they are the same hole. Welcome to topology

It's perfectly reductionist. You have defined our biology in exactly the same way medical texts do.

Now you're getting it!

Yes. It's called the gastrointestinal tract.

That's because a straw has two more holes than a sphere.