I think your view is valid, but I also think it's very "current lens in history" centric. The current conditions lend themselves toward people dooming about the future of humanity. Whether it's fears of nuclear war or it's crossing irreversible climate change feedback loops. These fears are real and valid, but are only a small blip in the overall history of humanity. Maybe this really is the end for most people or maybe it will one day be a footnote that was worked through and it may be seen in retrospect as something that obviously could be overcome.

Survival of life, of a species, is never guaranteed. From that standpoint, any number of things could result in the death of a civilization or even a species. But in the case of the human species, it has also gone on for a very long time and could yet go on for a very long time still.

I guess what I'm trying to get at is, the argument is not without any basis, but it also assumes a lot about similarity of systems and risks dipping into mechanical materialism with a sort of inevitability-based argument about the nature of development. We don't yet even know if other life has ever existed in a similar way to humans, or does exist now. Personally, I'm not convinced that the basis of the Fermi Paradox is even meaningful to begin with, but maybe I'm underestimating the scientific knowledge that goes into it.