1000xRESIST and Pathogenic
1000xRESIST was on a lot of underrated games lists last year when it came out, and I kept putting it off because the plot points I had heard about seemed very heavy, but it is a beautiful piece of art. It's a very cinematic game with a lot to say about identity, family, and the pain we inflict upon ourselves. Saying anything about the story would probably ruin it, but it's a walking sim with some light puzzle elements.
Pathogenic is a rougelite twinstick shooter where you play as an infection fighting through the human body and upgrading along the way by adding internal upgrades that power up external upgrades like tentacles that allow you to move or appendages that shoot/attack. It's almost the complete opposite of 1000xRESIST. Basically no story and all gameplay.