That was Cow and Chicken. Those were the “Buffalo Gals” (“won’t you COME OUT tonight” was their refrain if I recall).

You’re thinking of Cow & Chicken

Carlos Alquazari definitely did a lot more things, like reno 911. Hillenbrand was a creative executive on Rocco and went of to create spongebob. And, yes, go immediately and watch mr show. It's not just me saying it, its sooooo many comedians favorite comedy ever. Groundbreaking in so many ways.

Just seconding that mr show is amazing. Honestly every episode always has at least one great sketch and the way they run into each other is very fever dreamesque (in a good way). Like there usually isn't a clean cut between one sketch to another, they kind of just flow but the things linking them are usually odd - like it'll be at the end of a sketch and zoom in on a tv in the background and that leads to the next sketch. Variations of that sort of thing.

Rockos modern life was such a banger show too. I'm an almost 40 year old guy and I still occasionally watch episodes of Rocko or a courage the cowardly dog when I need that nostalgia hit.

Oddly enough, he only voiced Spyro once or twice and Tom Kenny ended up doing the remake and a couple games. Spyro has had way too many different VAs, lol.