I've also wanted to try out Guix for a while.. part of the reason I'm leaving a comment is just so I can recheck these posts later :P

But when I do I for sure will start out from nonguix because I'm quite confident that my hardware won't be supported (I even have a recently purchased Wifi 7 card that relies on ath12k module that I'm quite sure won't be in the official Guix repo.. maybe I'd even need to compile it myself..)

I see in the nonguix readme that there's a way to generate an iso that includes already a nonguix kernel, so I'll have a look at that.

It even looks like you can create a writeable image to run from a USB thumbdrive, which looks very interesting, I gotta try that!

guix system image --image-size=7.2GiB /path/to/this/channel/nongnu/system/install.scm
dd if=/path/to/disk-image of=/dev/sdb-or-whichever-drive-is-usb bs=4M status=progress oflag=sync

I've been burnt by Arch before which is what has got me into exploring other distros. I might ultimately end up again in Arch like you, who knows, but it looks like the way Guix works is well suited for hosting your own repo too.. I think I've seen before someone hosting their own Guix repo in github, including also a bunch of configuration for their system, which got me curious.