Selfhosted

I'm planning on setting up a nas/home server (primarily storage with some jellyfin and nextcloud and such mixed in) and since it is primarily for data storage I'd like to follow the data preservation rules of 3-2-1 backups. 3 copies on 2 mediums with 1 offsite - well actually I'm more trying to go for a 2-1 with 2 copies and one offsite, but that's besides the point. Now I'm wondering how to do the offsite backup properly.

My main goal would be to have an automatic system that does full system backups at a reasonable rate (I assume daily would be a bit much considering it's gonna be a few TB worth of HDDs which aren't exactly fast, but maybe weekly?) and then have 2-3 of those backups offsite at once as a sort of version control, if possible.

This has two components, the local upload system and the offsite storage provider. First the local system:

What is good software to encrypt the data before/while it's uploaded?

While I'd preferably upload the data to a provider I trust, accidents happen, and since they don't need to access the data, I'd prefer them not being able to, maliciously or not, so what is a good way to encrypt the data before it leaves my system?

What is a good way to upload the data?

After it has been encrypted, it needs to be sent. Is there any good software that can upload backups automatically on regular intervals? Maybe something that also handles the encryption part on the way?

Then there's the offsite storage provider. Personally I'd appreciate as many suggestions as possible, as there is of course no one size fits all, so if you've got good experiences with any, please do send their names. I'm basically just looking for network attached drives. I send my data to them, I leave it there and trust it stays there, and in case too many drives in my system fail for RAID-Z to handle, so 2, I'd like to be able to get the data off there after I've replaced my drives. That's all I really need from them.

For reference, this is gonna be my first NAS/Server/Anything of this sort. I realize it's mostly a regular computer and am familiar enough with Linux, so I can handle that basic stuff, but for the things you wouldn't do with a normal computer I am quite unfamiliar, so if any questions here seem dumb, I apologize. Thank you in advance for any information!