I binged the entire archive like 15 years ago and it's all about taking these characters who seem kind of mundane but are really tangled messes of weird issues and putting them in situations that are at once banal and absurd so they can react in ways that play off and expand on that. There's also usually a little bit of a buildup to the gags, so just seeing single strips in a vacuum loses most of the impact.

Overall it's a very dry sort of absurdity that sort of wallows in itself. It's kind of like if King of the Hill was a webcomic about anthropomorphic animals and instead of the banal hell of suburban Texas it was some nonsense fever dream world that was at least a few degrees more absurd.