I'm going to be trying esketamine treatment soon. I'll tell you if it's helpful. As with other commenters in this thread, I've had incredible periods of relief after psilocybin shrooms. Just 4 trips, but that was followed by months of improved mood and functioning overall. I'm hoping esketamine is similarly effective for me. It's legal and FDA approved now by the way, so perhaps look into a psychiatry practice near you that provides the service.