this post was submitted on 08 Aug 2023
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[Outdated, please look at pinned post] Casual Conversation

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Last night was the first time in a month when I had a full night of sleep. Now I've been waking up at 8AM instead of going to bed at 2 PM. Don't have a lot of people to share with but I'm not sure how to describe how I feel. It's like the absence of a headache I didn't know I had. My body feels much lighter and energetic. Hopefully I'll get back to cooking for myself this week!

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[–] [email protected] 4 points 1 year ago (1 children)

Different classes of antidepressents have different timeframes and take effect differently. SSRIs certainly behave as you say, but others such as Trazadone (a mixed agent that works seretonen and andrenergic receptors) or Buproprian (norepinephrine and dopamine reuptake, nicotinic receptors) have very different profiles.

Trazadone works rather quickly, has minimal suicidal ideation, and has a side effect of making you sleep. Its often prescribed off-label for insomnia, and always has the instruction to only take at night, before bed.

Buproprian takes full effect within 3 or 4 days o, the first dose. It also is nit certain whether it needs a full titration schedule to discontinue, In trials, it was not distingaishable from placebo in causing suicidal ideation.

Based on OPs report of immediate sleep quality improvement, I would certainly not be surprised if short or long term trazadone were part of their prescribed depresshon management strategy. Its often prescribed in tandem with other agents as well, which we also do not know about.

TLDR: theres more than one kind of antidepressant, they have different mechanisms and side effects, and we don't actually know which ones OP is using

[–] [email protected] 0 points 1 year ago* (last edited 1 year ago) (1 children)

They just said they took a sleep aid and who takes Trazadone for depression? I've been prescribed almost every med for it and Trazadone was only for sleep.

[–] [email protected] 2 points 1 year ago (1 children)

I took trazadone for depression, its the primary on-label use. And they hadn't mentioned the sleep aid when I started the comment

[–] [email protected] 1 points 1 year ago

Interesting. Most sleep meds I've been given were always originally made for depression, or vise versa. Pharmaceuticals always seemed to be an educated guess followed by trial results. Not an exact science. It sucks.