I mean, don’t put too much stock in a label like that. Someone who never curls any weight will experience “bicep dysfunction” in the sense of not being able to sufficiently and consistently move stuff around.
But it’s just atrophy. The brain can and does atrophy. It loves to fucking atrophy. The way to get it to stop atrophying is two things:
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Exercise keeps your brain big, dense, and well-connected
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Using your brain is necessary to prevent the atrophy. Unfortunately you can’t just use any part of it. You have to use all the parts you want to keep strong.
If your prefrontal cortex isn’t powerful or flexible enough to succeed in life, you can exercise it to make it more effective. Meditation is one thing that does this, for instance.