I've had issues that I've been able to work around.

I have previously had the error, "settings could not be applied", which I worked around by uninstalling my YouTube updates, installing the recommended version and clearing revanced manager data. I now get an error about not being able to load the original APK. I work around this by deleting the two apks in /data/abd/vanced before patching.

I'm rooted and have to repatch on each reboot. Not complaining, just want to share my experience in case it helps others.

I love revanced, and feel so thankful for it. I can't afford YT premium, without revanced I would miss out on so much great content.