Me personally? I've become much less tolerant of sexist humor. Back in the day, cracking a joke at women's expense was pretty common when I was a teen. As I've matured and become aware to the horrific extent of toxicity and bigotry pervading all tiers of our individualistic society, I've come to see how exclusionarly and objectifying that sort of 'humor' really is, and I regret it deeply.
Is lame ableist? I knew about the other 2, and I think anyone else growing up in the 2000s used them at some point (myself included, don't anymore though), but I've never heard of lame as being a slur.