I suck at the game, so winning isn't an option for me. But I really like either going poison or daggers for the skull wearing guy. I haven't even bothered with ascension as I'm still trying to do the keys thing while beating a run with a single character.

I'd say the closest I've played to Slay the Spire's "pick a path" style deck builder would be Peglin and One More Gate. Peglin is definitely a lot closer to Slay the Spire as you start off a blank slate every run (minus custom mode), whereas One More Gate is, so far, you do a run, come back to the hub area, buy/sell cards/upgrades, do another run to get slightly further.

Pretty much the only other deck builders I have are ones where you don't get to choose where you go next and go from battle to battle without any path choices or chance based event areas (Shotgun King: The Final Checkmate and Ardor).