I'm not sure exactly what brainrot refers to. I assume it means a loss of cognitive ability due to lack of mental exercise. If that's what it is, it can be modified, yes.

We have years of data showing that stimulating your brain is necessary. One example would be doing Sudoku puzzles, another would be playing the memory game (you have a bunch of items in a box, you uncover the box for a short time, then attempt to remember as many things as possible after it's been covered up again).

When they say the brain is like a muscle and needs exercise, it sounds cliche but it's absolutely correct.