I can confirm. I run the game unmodded and it is downright unplayable. It crashes within seconds of starting the game. Sometimes it lasts a few minutes and lets you play. But I swear if you manage to get close to complete a mission it will crash just in time so you miss the extract and don't get your rewards.

Haven't been able to complete a mission since the update. Arrowhead seemed to prioritize going after hackers (which I have never encountered) over the game experience for everyone else.