Python is great for standalone scripts/CLIs with standard system dependencies. For actual apps you want venvs, probably managed by uv these days.

I've written 1000s of python CLIs/scripts over the years, typically wrapping APIs for otherwise shitty enterprise and SaaS software (also many one-off scripts for ETL).

Nowadays, AI writes these scripts in a fraction of the time (and reads the shitty API docs / otherwise figures it out) and my CLI toolkit is better than ever (with $0 ongoing cost). Calling MCPs from CLIs is also interesting, as some vendors never had usable APIs before now.