Studio ghibli's Miyazaki (cant be bothered to look up his first name, but hes not the dark souls Miyazaki) is famously incredibly depressed/nihilistic but also makes incredible films and simply cant be forced into retirement. Pain does make art.

I was going to say food, but then I remembered every long-time cook can handle hot things barehanded because they've burned themselves so many times they've lost sensation in their fingertips.

Take your favorite musician or act and listen to their couch surfing, barely eating first album then listen to their 20 year run, financially secure album and you'll have your answer.

Same for comedy. I think a bit of trauma is required to be a good comedian.