It does not make sense to me why people would want to live beyond 50 years old, especially since health problems start becoming more frequent around that age.
Which makes me ask: Why do people wish to live long beyond the age of 50?
Because we are just a small part of something big we don't matter at all? I understand your point but I completely disagree with it. "Meaning" is an arbitrary and completely nebulous concept. To your point there is one incredibly small chunk of time we as organisms have to experience the universe. Why shouldn't we try to enhance, enjoy, participate, improve for others and feel as much as possible? What does "meaning" have to do with it at all?