Mass Effect is a very slow, very forgiving combat experience unless you’re playing on insane. Pretty much everything auto locks on or has some sort of AOE component. You could pretty much play the game rarely firing a gun if you really are worried about it. But even then it’s not bad at all.

Console, and it was perfectly fine. It's in third person, which helps, and there are powers which don't need to be aimed in real time. I never felt like using a mouse and keyboard would make me significantly better.