Slightly lower ram speeds, which might result in slightly slower load times, but I doubt you'd notice it.
The minimum amount of ram you can find on a single stick is lowered from 16gb > 8gb, which gives you the option of a 2 x 8gb kit for a total of 16gb total in dual channel. You always want dual channel (aka sticks in some multiple of 2) since it increases bandwidth. You can still get 2 x16gb kits for a total of 32gb in DDR4 if you need it, but you at least have the option for less. And if you get a 4 slot motherboard you can start with a 2x8gb and buy a second kit later.
And new production of DDR4 hardware is starting to ramp up to help get around the prices od DDR5. AMD is about to rerelease the Ryzen 5800X3D, which is the top gaming CPU for DDR4.
If it helps, here's my current system:
- CPU - Ryzen 5800X (not 3D)
- RAM - 32gb DDR4
- GPU - Radeon RX 9070XT
I play on a 1440p 144hz monitor and while not everything runs at max frames, I don't recall anything going below 60fps. That being said, I don't have or play BL4.
I'm happy with my system, but it might not fit your exact use case. I just wanted to let you know about potential options that might work for you. Always check the requirements for the specific games you want to run.