counterpoint:

The first reliably documented report of Psilocybe semilanceata intoxication involved a British family in 1799, who prepared a meal with mushrooms they had picked in London's Green Park

It's true in that almost every food item is made "with science" (university-educated food technicians, biochemists, engineers etc.) these days, but you hardly need science to make common drugs like alcohol, caffeine or nicotine. Coffee and tobacco are just plants, and fruit will spontaneously start fermenting all on their own.