Yes, and no.

If the password is stored properly (hashed and salted), then a high entropy PW will make it nearly impossible for your PW to be extracted from a database dump / data leak

On the other end, if the PW is stored as plain-text, a high entropy PW is useless.

In between, a weak hash algorithm or no salt, a high entropy PW still makes it much harder to extract, but it depends

In general, 2FA is more secure, since it combines 2 different methods of authentication.

• something you know: password
• something you have: the 2FA token (usually on a phone)

This protects the service (as well as the user) against a broader range of attacks. Such as

• password reuse (which nearly everyone does)
  • this is particularly bad, because you're increasing the chance that a weakly designed system will have it's data stolen, your reused PW and username included
• phising attempts
  • somewhat
• low entropy passwords
• replay attacks
  • since 2FA tokens are usually time bases (TOTP), they expire after a few minutes and can't be reused if an attacker manages to intercept one

Among others