I've yet to find a game that I couldn't play (though knowing me I probably forgot one or two). It's mainly mods that I've not been able to implement, as some of them require running an exe file.

However I've had very helpful people tell me I can do all that in a wine instance or something similar so mainly it's just my own laziness (and lack of understanding about how to "do it in a wine instance") that's holding me back from installing fancy modpacks or playing the latest Stalker gamma version.

Also i don't play multiplayer stuff so the anti-cheat thing issues don't usually apply to me. So there's that.