Ibuprofen is not recommended for people with hypertension and with prolonged use, leads to leads to stomach issues. And aspirin lowers platelet adhesion, so also carries risk for people with who bleed easily. Everything carries a risk, that's why studies help show what those risk are and how to minimize/avoid. That's the nuisance missing from the national discussion, kinda intentionally. The right dose is therapeutic, any more and kiss your liver/kidneys goodbye for most drugs.