I’ve read the first study already, it doesn’t comment at all on the hunger signaling aspect.

The second study is just proposing this as a mechanism which may account for weight regain. They spin off pretty quickly into a more matter-of-fact tone while presenting the hypothesis itself, but at the moment it remains speculation. I obviously haven’t had the time to click through to every reference in there, but so far the links I have checked similarly lead to speculation.

Basically I think it’s somewhat dishonest to present this hypothesis as a statement of fact. I feel like the inevitable result of this mischaracterization will cause people to not even try. Why bother if something is probably impossible, or only one in a million could do it?

Thank you for linking it however, and I will be very interested to know if Professor MacLean verifies the concept. Of note, in the conclusion they propose that environmental and behavioral interventions will be important for combatting this effect, if it does turn out to be true

Could you direct me to the paper where it was proven? There seems to be a notable amount of bad journalism and broad misrepresentation of the science on this topic.

We are basically discussing whether or not obesity is an inescapable condemnation, so we should not sensationalize the topic whatsoever, and we should especially not present it as a fact if it is not a fact

Yikes, dawg.

The brain is the body. They aren't separate.

I brought up caloric excess in my other comment. I'm aware caloric excess causes weight gain simplisticly, but like I said, that is a simplistic take that ignores eveything else about the body and how people function as bodies. It's a great attitude if you have an eating disorder or want to punish people for being fat though while ignoring their vitamin needs.

Food cravings are physiological in nature. Why people even WANT to eat when they already know about calories is what matters.

Foods are made of vitamins, minerals, proteins, carbs, fats (which many are vitamins), and probably stuff I'm not thinking of. Plus we eat stuff like microplastics, dust in the air, lint, whatever incidental things. And then we also have a microbiome that interacts with all this, and that respond adaptively to pathogens, eg hydrogen peroxide producing bacteria, plus the pathogens themselves. We come into contact with pathogens a LOT, and most of the time our immune system just deals with it, it's not a big deal. Same with cancer actually.

There's stuff going on under the hood, is my point, and we don't know what our cellular buddies are dealing with and if they need more of a certain vitamin or not, they don't burden us with minutiae. We just think, "fuuuuck, a goat cheese hummus salad would slap right now," because biochemical pathways in our brain light up and we start feeling hunger.

Calories follow basic thermodynamics, yes, but your body is very complex. The goal isn't thin and malnourished and sick, the goal is usually healthy and fit and feeling good.

And if you’re burning more energy than you take in, your stores are going to deplete

This is what I mean by simplistic. You wave your hand and say your body is simply "burning energy," when it is actually an endlessly intricate bioelectrochemical dance between entire cities of unicellular life and tiny multicellular life (and some viruses) with whole lives of their own. It's crazy what happens inside us and how we adapt.

There is actually a lot of literature (like since before the 50s) on fat soluble vitamins and I linked some elsewhere itt for general reading on how it relates to insulin and Ozempic in simple terms. That you don't know that, that I know more than you, is obvious and you should probably stop externalizing. There's also tons of modern dieticians and nutritionists (with doctorates) who practice this exact philosophy, and indeed it is what our entire recommended daily intake is based on.

Supplements are made from food, especially the ones I listed. Go look at the ingredient labels. And people know they can get vitamins from food and can look that up, as that is common knowledge.

They don't HAVE to take a stranger's advice lmfao.

Again there's no safety issues with the supplements I was talking about. I'm aware of which supplements are more dangerous.

We didn't evolve to breathe car exhaust every day and we do, so maybe there are external oressure we have these days we didn'thave before. 0I think our bodies are very adaptable given the wide range of biomes (incl sun exposure/vitamin d availability) we occupy, and we might need some extra vitamins every now and then. Supplement or whole food, either way.

People overdose on selenium with brazil nuts pretty often, because it takes so few to overdose and they don't realize. Arctic explorers ate a ton of polar bear liver with 1,000,000 times recommended retinol in one bite, one died and the other's feet sloughed off and almost died. You yourself simply don't eat food sources that will kill you, because everything you eat is from a super market lol and safe. Some whole foods can kill with vitamin dosages and can vary widely in their dose. With supplements, you know the exact amounts and are somewhat less likely to "overdose" based on that alone. Plus, you can take vitamins individually/independently for a while and see how your body responds to know if that specific vitamin is helpful or not, then choose a whole food source once you understand what vitamins you need.

Drs say that because they don't want you to take retinol in excess or be careless with your doses. It's okay to take a normal daily dose. Some doctors have eating disorders and fat phobia too by the way, and those doctors tend to be pretty ignorant about fat soluble vitamins and nutrition itself. And again, vitamin k has no upper threshold at all. We inject it into newborns at pretty high doses and have since the 60s. You aren't going to get "toxic levels" of vitamin e or coq10 in your body either lol unless you deliberately megadose.

Ps liver and heart are good whole food sources of these vitamins

Pss laughable you criticize recommending vitamins when people here want to casually take Ozempic because their favorite anorexic celeb did it and looks great (on tv with filters and editing). And just shows your anger is misplaced