According to the article, scientists have created synthetic human embryos using stem cells, without the need for eggs or sperm. These embryo-like structures resemble those in the earliest stages of human development, but they do not have a beating heart or a brain. They are not considered human embryos, but rather embryo models. However, the work also raises serious ethical and legal issues, as there are no clear regulations governing the creation or use of these synthetic embryos. Some bioethics experts have expressed concern about the implications of these models for the definition and respect of human life.

(1) Synthetic human embryos created in groundbreaking advance. https://www.theguardian.com/science/2023/jun/14/synthetic-human-embryos-created-in-groundbreaking-advance. (2) Scientists report creation of first human synthetic model embryos. https://www.cnn.com/2023/06/14/health/human-model-embryo/index.html. (3) What are synthetic embryos? - Maize. https://www.maize.io/magazine/what-are-synthetic-embryos/. (4) Scientists Create Synthetic Human Embryos | Newsmax.com. https://www.newsmax.com/health/health-news/embryos-synthetic-human/2023/06/14/id/1123609/. (5) Scientists create world’s first ‘synthetic embryos’ - The Guardian. https://www.theguardian.com/science/2022/aug/03/scientists-create-worlds-first-synthetic-embryos.

Osimertinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that binds to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletion) that predominate in non-small cell lung cancer (NSCLC) tumours following treatment with first-line EGFR-TKIs². It exhibits a nine-fold greater affinity for select EGFR-sensitizing and T790M-resistance mutations than to wild-type EGFR¹.

(1) . https://bing.com/search?q=osimertinib+mechanism+of+action. (2) DRUG NAME: Osimertinib - BC Cancer. http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Osimertinib_monograph.pdf. (3) Mechanism of Action – TAGRISSO® (osimertinib). https://www.tagrissohcp.com/moa.html. (4) Osimertinib: Uses, Interactions, Mechanism of Action | DrugBank Online. https://go.drugbank.com/drugs/DB09330. (5) Mechanisms of osimertinib resistance and emerging treatment ... - PubMed. https://pubmed.ncbi.nlm.nih.gov/32693293/.

The article talks about the possibility of creating artificial wombs capable of supporting humans across the full nine months of development. It also mentions that even if scientists are able to overcome the scientific hurdles and create artificial wombs capable of supporting humans across the full nine months of development, society might reject them. It also discusses how artificial wombs will alter the relationship between men, women, and fetuses such that reproduction is effectively ‘degendered’.

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