all 46 comments

sorted by: hot top controversial new old
[–] 1 point 1 hour ago

Paranoid?

Tummo breathing (like from the Wim Hof Method), and CBD isolate, and perhaps most of all, Caryophyllene.

Not paranoid any more. What remains are legit concerns.

  • source
  • [–] 4 points 1 day ago (1 child)

    I only ever got paranoid that I might be caught smoking before my parents knew I smoked and it was illegal here.

  • source
  • hideshow 2 child comments
  • [–] [S] 4 points 1 day ago (1 child)

    Did you at least give your parents a goodnight handshake while you were high as a kite? ^^

  • source
  • parent
  • hideshow 2 child comments
  • [–] 12 points 2 days ago (1 child)

    A few things.

    (1) CBD is an effective antipsychotic, but the consumer market for weed has been selectively breeding it out in favor of pure and dense THC strains.

    (2) The way THC works on anxiety is a biphasic curve where at lower doses it reduces and at higher it increases. And because the efforts have been at increasing potency of flower, you can have a significant dosing range between a bowl of one strain and another.

    If you would like to stop having a bad time getting high, try to actually measure and control the dose to a lower amount than what triggers the anxiety, and try to get a stain that has CBD alongside the THC (or just a high CBD strain to mix in).

    A 2:1 THC:CBD ratio is a really good one personally. (This was the ratio of the 8th century BCE temple cannabis and turned out to be a great ratio when I replicated.)

  • source
  • hideshow 2 child comments
  • [–] 5 points 1 day ago (1 child)

    There is work from the same group of researchers showing that CBD + THC actually exacerbates the effects of THC on psychosis symptoms in people with schizophrenia: https://pubmed.ncbi.nlm.nih.gov/40702165/

    Plus I wouldn't be surprised if some of the beneficial effects of a gram of CBD on psychosis symptoms has to do with pharmacokinetic effects (CBD inhibits enzymes that metabolize a lot of drugs, meaning a gram of CBD in someone with Schizophrenia that is taking other medicines would increase their blood levels of the other medicines).

    Not to say playing around with some CBD is a bad idea if it works for you, but the actual hard evidence on CBD acting as a counter weight to THC's effects is pretty scant.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 2 points 1 day ago* (1 child)

    in people with schizophrenia

    If OP has schizophrenia, my advice would adjust. But there's many studies (not just one, which one should always be suspect of until more/meta) about the blunting effects of CBD on THC's more negative effects on the general population going all the way back to 1982.

    Here's a meta-analysis from 2019.

    And this is a study that looked at fMRI differences when CBD was or wasn't present.

    So the 'scant' evidence is the opposite finding you are citing (which probably has more to do with the nuances of schizophrenia making it an outlier), not the claim CBD tempers the psychosis of THC in a normative population which is about as well studied as a thing can be when one component is a scheduled substance.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 4 points 1 day ago (1 child)

    I brought up schizophrenia as your initial cited study mentioned the antipsychotic effect of CBD in people with schizophrenia, where you claimed that CBD is an antipsychotic.

    The meta-analysis you've cited says that CBD does not consistently moderate the effects of THC across all outcomes and finished with a pretty lukewarm conclusion, that "CBD may interact with some acute effects of THC".

    Here's another meta-analysis that also finds no consistent evidence that CBD improves the acute symptoms of THC: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30074-2/fulltext

    My point being - the cannabis research field is not in a place to make any kind of concrete claims about CBD reducing the effects of THC. If it were, you'd see strong conclusions coming from meta-analyses, and cannabis companies wouldn't stop citing the research when promoting their balanced CBD-THC strains.

    I don't think it's healthy to give people the advice that there is concrete evidence that CBD will make THC more enjoyable for them. There is no magic bullet that will make THC enjoyable for some people - although again, more power to you if it works for you.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 2 points 13 hours ago*

    The paper and supplemental materials you provided didn't explain their decision making on how they are representing their opinion on them, but here's the abstracts of the four papers they concluded as no effect (and as a reminder, OP was asking about paranoia, not psychosis).

    Post-THC, there were lower PANSS positive scores in the CBD group, but this did not reach statistical significance. However, clinically significant positive psychotic symptoms (defined a priori as increases ≥ 3 points) were less likely in the CBD group compared with the placebo group, odds ratio (OR)=0.22 (χ²=4.74, p<0.05). In agreement, post-THC paranoia, as rated with the State Social Paranoia Scale (SSPS), was less in the CBD group compared with the placebo group (t=2.28, p<0.05).

    • Englund et al. Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment (2013)

    In a second experiment, six healthy volunteers were administered Delta-9-THC intravenously on two occasions, after placebo or CBD pretreatment to examine whether CBD could block the psychotic symptoms induced by Delta-9-THC. […] In the second experiment, pretreatment with CBD prevented the acute induction of psychotic symptoms by Delta-9-tetrahydrocannabinol.

    • Bhattacharyya et al. Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology (2010)

    Results indicated that THC increased overall scores on the PSI, negative symptoms on BPRS, and robustly impaired episodic and working memory. Co-administration of CBD did not attenuate these effects. CBD alone reduced PSI scores in light users only. At a ratio of 2:1, CBD does not attenuate the acute psychotic and memory impairing effects of vaporised THC.

    • Morgan et al. Individual and combined effects of acute delta-9-tetrahydrocannabinol and cannabidiol on psychotomimetic symptoms and memory funct (2018)

    The fourth study was in conference notes and this appears to be only one of two studies to cite it. The same cited author the same year contributed to the review Cannabidiol as a Potential New Type of an Antipsychotic. A Critical Review of the Evidence (2016) which focused on a study the Lancet piece you cited appears not to have included:

    The first controlled, randomized, double-blind clinical trial was conducted by Leweke et al. (2012). During this 4-week trial 42 schizophrenic patients received either cannabidiol (600–800 mg/day) or amisulpride (600–800 mg/day) – a highly effective second generation antipsychotic, selectively antagonizing D2/3 receptors (Leucht et al., 2002). Both drugs resulted in significant clinical improvement of both positive and negative symptoms of psychosis. The efficacy of cannabidiol was comparable to that of amisulpride, but, importantly, cannabidiol revealed a superior side effect profile when compared to amisulpride.

    That paper has over 900 citations.

    The Lancet is a gold standard, presumably they had their reasons to count the conference notes results twice in both CBD only and CBD+THC's handful of studies that made their cut but not include this one.

    Now…

    If this was a user in the midst of a psychotic break thinking of just adding in CBD but keeping up with THC, or someone with schizophrenia, my advice would be to avoid the THC because of the potential harms.

    But OP was asking about paranoia.

    And so yes there's studies where CBD has been shown to be an effective antipsychotic on its own.

    And there is evidence to support that CBD reduces the effects of THC via fMRI and paranoia evaluation.

    There is also conflicting evidence as to the reduction of the psychosis effects of THC when high. Which OP isn't expressing concern about.

    (Additionally, even if it were only as effective as placebo for paranoia, placebo effects are notably large for generalized anxiety, at 1.85 in Huneke et al, Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review (2024).)

    Also, looking over things again now (and thanks for pushing it), the evidence seems like CBD may be less likely to be having measurable effect when vaporized vs other delivery routes. So ymmv.

    TL;DR: The side effect profile for CBD is minimal, and for a user simply concerned with not feeling paranoid when high, it's perfectly safe and appropriate to suggest adding it into the mix to see if it reduces the paranoia, as well as pointing out the plausible existing evidence for there being an effect.

  • source
  • parent
  • [–] 10 points 2 days ago (1 child)

    shit makes me anxious. maybe because i have adhd and am the only one in my house who is able to do “adult” things since my wife drinks and smokes and is always checked out and it’s therefore never “my” turn. so instead i go to bed early, in my own bedroom, and play everquest.

  • source
  • hideshow 2 child comments
  • [–] 7 points 2 days ago (2 children)

    “Breaker breaker, come in earth. This is rocket ship 27. Aliens fucked over the carbonater in engine #4. I'm gonna try to refuckulate it and land on Juniper. Hopefully they got some space weed. Over."

    I’ve been through enjoying it, to getting nervous over nothing and back to enjoying it again. This is over years and not just one day to the next.

    Body chemistry changes, medications, who you’re around, your mood can all play a part. Another person mentioned that sometimes it’s harvested too soon. You’ll get THC but if the terpenes haven’t fully developed you’ll have a different experience. This is why I dislike distillate (pure THC) and stick with good flower even when making edibles.

    You mentioned being in a state where it’s not legal. That’ll make things difficult to find quality grown cannabis. Not impossible but compare to some places that have legal drive thru pickup it’s a pain.

    If you try again use less than you’d think you should. Better it be low dose than uncomfortable.

  • source
  • hideshow 4 child comments
  • [–] [S] 7 points 2 days ago* (2 children)

    Oh, you've misread it. It's not illegal where I live. I could light one up right now next to a copper and it'd be fine.

    I think my body chemistry just changed over the years. Close to the big 40 these days.

  • source
  • parent
  • hideshow 4 child comments
  • [–] 3 points 2 days ago (1 child)

    Sorry, I did misread the post. You said you’re not in an illegal area but I read that as you are.

    You’re doing the best thing by listening to your body. I’m in a similar age range and understand. I had an experience where it suddenly wasn’t enjoyable and I stopped for a few years. If that ever happens again I’d likely be all done.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 4 points 2 days ago (1 child)

    Julian, make him do it riiiigght

    Ah yea, we got a report of some losers getting high and drunk in the street, playing space

  • source
  • parent
  • hideshow 2 child comments
  • [–] 3 points 2 days ago (1 child)

    Yeah, us. Fucking stoned right now. Got a problem with that?

  • source
  • parent
  • hideshow 2 child comments
  • [–] 4 points 2 days ago (2 children)

    Did we just become best friends!?

  • source
  • parent
  • hideshow 4 child comments
  • [–] 7 points 2 days ago

    Damn, it must have been tough exploring the galaxy for weed without any replicators or money

  • source
  • [–] 4 points 2 days ago (1 child)

    From my observations, if someone is already feeling on edge, weed does not help. And in most places, just living means you're on edge right now.

  • source
  • hideshow 2 child comments
  • [–] 3 points 2 days ago
    [–] 3 points 2 days ago (2 children)

    Opposite for me. Weed made me feel paranoid when it was illegal, or when my parents would shame me for smoking. Now there are no social consequences to smoking, so I have nothing to feel paranoid about.

    What are you paranoid about? Blackhawk helicopters?

  • source
  • hideshow 4 child comments
  • [–] [S] 6 points 2 days ago (1 child)
  • [–] 1 point 1 day ago (2 children)
  • [–] 6 points 1 day ago (1 child)

    The one with Slartibartfast- he said as if it should be obvious.

    Life, the Universe and Everything iirc

  • source
  • parent
  • hideshow 2 child comments
  • [–] 2 points 1 day ago (1 child)

    Thank you! People have been telling me to give these books a go, for a very, very long time now... This single scan intrigues me, the writing style seems to be up my alley.

  • source
  • parent
  • hideshow 2 child comments
  • [–] [S] 1 point 1 day ago

    Highly recommend. There's a 6th Hitchhiker's book written by Eoin Colfer (And Another Thing) with the permission of Douglas Adams' family. It's alright and completes the series.

    My favourite book, though, is Last Chance To See. He travels the world and writes about animals on the brink of extinction. After I read it, I hated mankind in general even more. Didn't know it'd be possible..

    The Dirk Gently books and Starship Titanic are good fun as well.

  • source
  • parent
  • [–] 3 points 2 days ago (1 child)

    In what manner are you consuming it?\

    If it's flower being used, I'd recommend trying to check the trichomes to see if you're getting early chops. Most flower on the black market is chopped before the trichs are able to go all milky, which can cause things like anxiety to spike.

  • source
  • hideshow 2 child comments
  • [–] [S] 6 points 2 days ago* (3 children)

    It's not illegal where I live, you can get good quality weed from reputable sources, but it just messes with me. Weed was fine with me up until my early 20s, but then it changed somehow. I'd only smoke the occasional joint every two months or so.

  • source
  • parent
  • hideshow 6 child comments
  • [–] 6 points 2 days ago (1 child)

    Your body and brain chemistry undergoes various changes over time, it could just be that it's no longer compatible with you. This has happened with a few buddies of mine, they're just no longer into it as it now either makes them go to sleep, or gives them anxiety symptoms.
    Many people still think cannabis is THE thing for everyone, but at the end of the day it's still a drug which can affect each of us differently.

    If you've already tried different strains and genetic lineages, and still have the same result, it may be something to consider.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 4 points 2 days ago* (1 child)

    Your describing THC overdose btw. Weed has become stronger and if you were happy with 12% but now all you can find is 20-30%. You only need to smoke 1/2 or 1/3 as much. Source medical patient and THC dependant.

    Or to put this in other terms, if you used to drink nothing but light beer and then switch to ipas you will find that you get drunk way too easy and it's not as enjoyable.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 7 points 2 days ago* (1 child)

    Not necessarily. I'm same as OP, happened also in my 20s (a long damn time ago).

    I broke my collar bone a couple of years ago, and when I ran out of pain meds, I would smoke a bit of hash. As in one max two hits on a hash spliff.

    The hash helped with the pain for sure, but every single minute I had to do full on mindfulness. Walking to the store about to freak out then reminded my brain "hey that's ok but we are walking now; go back to paying attention to you feet and arms."

    I've tried smoking recreationally throughout the years. In the past 25 years I've had a good experience exactly once, and Io am convinced it was because the circumstances were literally perfect for me, mentally and physically.

    So yeah even with tiny doses of different strains, it just turned on my and stayed turned. And it sucks, yes.

  • source
  • parent
  • hideshow 2 child comments