Might just be my inexperience with the library, but every time I end up with a pandas dataframe, I spend the next 4 hours trying to figure out the right sequence of index statements and function calls to get the data in the order I want. It always ends up feeling like I'm doing something wrong, and the only way to really tell is to run the code as far as I can tell. I don't use dataframes very often though, and I'm sure it gets easier with experience.
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