Any weird/controversial opinions? I'll start. Before the remake, the best version of Resident Evil 4 was the Wii version. The Wiimote controls old Resi's tank controls better than any other controller at the time. The PC version had a bunch of little bugs and detractors that the Wii version just doesn't have.
I'll extend this by saying that the Wiimote is actually pretty damn good for shooters, and particularly good for accessibility. Not having to cramp up my hands to press buttons is awesome for having arthritis. Aiming with the Wiimote and moving with the nunchuck just feel really natural, you barely have to move your fingers for anything.
The popularity of skill based matchmaking decimated game design that allows people of different skill levels to play together and progress in a multiplayer setting. Most games actually punish you for playing with better players on your team instead of allowing you to help somehow without being a liability. And when you are, the game is no longer winnable and people get extremely pissed off ensuing you won't get to play with them again.