I use a Violentmonkey script to do so

Sync let's you do it. Also possibly Connect? I forgot the other one, but i think it might be Connect.

Kbin allows users to do this (noting kbin isn't a client it's a compatible platform).

Connect does instance blocking and I think LiftOff does as well.

Give Memmy a try. I switched to it so I could block entire instances. It’s made my feed so much better!

There's differing opinions and then there's just shittalking. When it comes to differing opinions most of Hexbear interactions deliberately (by the admission of their own users) fall under shittalking. They deliberately antagonize and troll anyone with a different opinion because in their mind anyone who doesn't agree with them should be trolled. You don't get differing opinions from Hexbear, you get a bastardization of a differing opinion. One that is different only on the basis them telling you you're wrong, and in most cases even that has to be intuited.

Nobody should wade through shit to get a few nuggets of gold which is why most people just block Hexbear.

You need both. For a comment you even need the community instance, the poster instance, and the commenter instance to all be federated

Ah yes, Xi Jinping