So I've been doing subcutaneous E injections for close to 11 months at this point¹, and my most recent one turned out kinda weird. It hurt a bit more than usual going in, there was a lot less resistance when pushing the plunger in (got everything injected in less time than normal), and there was significantly more blood than I'm used to after removing the needle (typically there's only a tiny speck if anything, this time nearly the entire cotton part of the band-aid is stained red). It's been about 2 days now and there's a ~1cm diameter bruise at the injection spot, which is also something I haven't seen before.

The only thing I can think of is that I must've gotten unlucky and managed to hit a blood vessel. If that is the case though, my understanding of how injections work tells me that this will dramatically affect the release curve - rather than being deposited into fat tissue and slowly being released into the bloodstream, I assume this would mean much of the EEn was dumped directly into the blood where it would then be converted into E2 and consumed/destroyed within hours or a few days at most. Am I overthinking this? Should I do another shot to make sure my levels don't crash down in case my hypothesis is correct, or should I just stick to my usual weekly schedule?

¹ probably not relevant, but including this anyway: I'm injecting 0.13 mL of EEn (40 mg/mL, in MCT oil) once per week using 30G, 1/2in long needles

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[–] 4 points 1 day ago*

I agree with the top comment of this thread. I had an injection the other night that hurt more than usual and some of the actual liquid pushed back out the injection site. Still a bit sore a day later. I just didn’t fully relax my leg I think. Something like that. Some combo of not getting the needle far enough and my leg being a bit tense. I was kind of rushing so maybe that’s part of it. Wasn’t really able to do the regular ritual.

Definitely monitor and such. Doesn’t seem so out of the ordinary that you need to out yourself to you doctor right away, but seek medical attention if it doesn’t improve from how you described it. Like bruising hopefully starts to fade from here on out.

Could go to an urgent care or something that isn’t your doc?? Just say it happened with your prescribed meds or something. Should be able to keep those records separate if you play your cards right. Some folks might have thoughts on that for other reasons, but it’s always something I keep in the back of my head if I am ever doing DIY.

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