As of today on Linux SteamVR:

• desktop preview does not work on Wayland DEs
• dropped frames cause reprojection errors causing visual stutters
• dropped frames cause "vsync_to_photon" timing errors thus causing input lag/drunken vision
• exiting any VR game crashes SteamVR Dashboard and sometimes desktop Steam UI too
• SteamVR sometimes launches legacy UI with missing features
• SteamVR frequently fails to launch
• SteamVR does a partial "silent launch" - no desktop confirmation of VR running, but you see image inside of a headset
• SteamVR can't automatically switch audio device to headset speakers, nor supports audio mirroring

Issues which don't apply to Steam Frame but are still technically issues on legacy "Linux supported" headsets:

• Base Station power management does not work (Vive 1.0/Index 2.0)
• Room preview/cameras do not work
• Volume buttons do not work (HTC Vive Pro)

And probably many more issues I'm missing