It really worked so well for the US killing the leader of Iran. Basically won them the war in one stroke. /s

We have an obvious and pertinent example of a decapitation strike on political leadership not being a particularly good strategy from a military standpoint. Iran seems to be conducting itself much in a much less emotionally reactive way than this, so I doubt we'll see it unless they really are falling apart internally and are just trying to lash out in revenge on their way down.