The way the runes warp on the pages look more realistic, but can make them harder to parse at a glance, which can definitely be troublesome.

That's funny, because I personally make no attempt to memorize the glyphs in a run. I just inspect every scroll in the shop, and it tells you the name before you buy it. If I see one scroll I like, I can memorize the glyph for one second to count how many are being sold.

Glyphs on unidentified scrolls don't really matter, and ID'ed ones in inventory have icons. If I see a scroll on the ground, I pick it up. The only time I inspect scrolls on the ground is if I want to use a Wand of Fireblast. If it's Upgrade, I blast away. And if I think a scroll might be Transmute (from one of those choose-three rooms) I use the note system to label it.

So when exactly are the glyphs troublesome? They could be blank icons, and it would barely affect my gameplay. 😄

...maybe just an option to add a symbol to potions similarly to scrolls?

ID'd potions already have symbols, although Toxic Gas and Paralysis can be confused since they only vary by color.

Elixers don't have symbols, though.