I will say---I don't want to just focus on the negative---that there are also some benefits to being small. Worth taking those into account. I was around during very early Reddit, and there's stuff that I missed on later Reddit, as the scale became really large. Enjoy it while you have it, since you may not have it forever.
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Little spam and similar stuff. Facebook has, like...3 billion MAU. We have 50k MAU. Spammers have an overwhelming incentive to focus on places like Facebook. I remember early Reddit also being pretty clean of that. Was nice while it lasted.
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People read what you write, if you want to write things. We don't have a lot of comments and such, so what people do write tend to get read. Sometimes by damn near everyone on the Threadiverse, not even people explicitly following the community. I remember watching /r/Europe change from a point where there was little traffic to the point that if a comment didn't happen early and catch traction, it'd probably get buried and never have anyone read it. That's kind of discouraging, if you want to put effort into writing a solid comment.
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You can recognize people. I remember talking with Reddit's founders and knowing Reddit usernames. Over time, that kind of went away, and I think that it gave something of a "you're never as alone as in a big city" vibe. Today, on smaller subreddits, you could certainly recognize people, but on Reddit as a whole, it's harder. I can recognize a number of users here. By the same token, it's much easier to have a noticeable impact, be it on policy, client/server software, or whatnot.