Aluminum dust exposure and risk of neurodegenerative diseases in a cohort of male miners in Ontario, Canada

https://pmc.ncbi.nlm.nih.gov/articles/PMC8504163/

Aluminium exposure leads to neurodegeneration and alters the expression of marker genes involved to parkinsonism in zebrafish brain https://www.sciencedirect.com/science/article/abs/pii/S0045653522022457

From nature summary

Aluminum Neurotoxicity in Neurodegenerative Diseases

"Aluminium crosses the blood–brain barrier via transferrin-mediated pathways and can catalyse the generation of reactive oxygen species, disrupt mitochondrial function and promote neuroinflammatory cascades. At the molecular level, aluminium ions can bind to amyloidogenic proteins, facilitating the oligomerisation of β-amyloid and stabilising hyperphosphorylated tau, thereby amplifying the formation of senile plaques and neurofibrillary tangles characteristic of Alzheimer’s disease. In Parkinson’s disease and other movement disorders, aluminium may contribute to dopaminergic neuronal loss by exacerbating mitochondrial dysfunction and α-synuclein aggregation. Epidemiological studies have detected elevated aluminium levels in post-mortem brain tissue from patients with Alzheimer’s disease, multiple sclerosis and autism spectrum disorder."

https://www.nature.com/nature-index/topics/l4/aluminum-neurotoxicity-in-neurodegenerative-diseases