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Transcript
4 Panel Comic
Panel 1: Spider biting a hand
Panel 2: Hand in the Spider-Man pose shooting web from their wrist
Panel 3: Dog biting a hand
Panel 4: Arm getting a rabies vaccine shot
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I didn't get it until I read the transcript. I thought that the second panel was a jab with barbed wire (tetanus risk) and that the joke was basically "if your body is punctured, be sure to treat it by puncturing your body".
I actually think I find that reading more fun than the intended one.