I've worked 2nd (afternoon), swing (evening), and 3rd (overnight) shifts for the majority of my life. I recently moved into a training position where I'm Monday through Friday, 8am to ~5:30pm (I get OT while I'm cleaning up and writing reports).
As much as the 2nd/swing/3rd shifts screw with your life in other ways, the difficulty in scheduling any kind of life services outside of working hours is maddening. Doctor's appointment? Nope. DMV? Maybe Saturday, if you're lucky. Chaperone your kids field trip? Hahahhah no.
I don't want to burn sick time for a doctor's appointment (I need to save those for when my kid is actually sick), and I sure as hell don't want to use up a "vacation" day for it. How tf are you supposed to get anything done?
Where I work, they don't really give a shit if you have to go to an appointment or whatever. You just let people know you're going to be out at such and such time and that's it. No micromanaging of time since we're all adults and know what our deadlines and deliverables are. It's a salaried position, though.
If I had no flexibility at all that would definitely be pretty miserable.