Richard Dawkins: Men have penises and make sperm, women have wombs and make ova. That is objective truth. If you lack a vagina you cannot be referred to as she/her, and if you lack a penis you cannot be referred to as he/him.\ Also Richard Dawkins: This network of silicon and fibre optic cables running a fractal Markov chain is clearly a woman who one should obviously refer to as she/her.
(Paraphrasing a quip by @2something@transfem.social)