Prior to transitioning I always said the two substances by brain required to function were cannabis and either caffeine or adderal, stimulant+weed kept me functioning tolerably even when I really didn't feel like it. Now estradiol is on the list too lol

I dunno, I am no expert, it work for me. I usually smoke the day I remote work and take coffee the days I work in the office. Do what work for you ;)

Weed can also kill creativity. I basically stopped playing music when I started using it for pain relief (pain that didn't effect my playing)