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Nearly half of Americans hold some form of vaccine skepticism, poll finds
(www.independent.co.uk)
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You really can't get away from that. The alternative is that you test your new drug for 50 years before selling it to see if there are any bad long term effects. What we currently do is test for a shorter time, if everything looks good you can start selling it. However, the drug company and FDA do post market surveillance to find things like your examples.