Is there any chance for a resolution of this story where Caleb's mother does not die?
Well, she could be in line as the next season's big bad, somehow. Or get trapped in a transport buffer or something. The chances are marginal, but it could happen.
I'm curious if they'll be able to think up a satisfying alternative to the "lost relative is found/lost relative dies tragically" trope. This show has surprised me a few times, so I'm cautiously optimistic.
I haven't checked to see if Tatiana Maslany has been mentioned in connection with season 2 shooting, but that might be all the proof you need to her fate.