I mean I personally love anime stuff and I'm a major Touhou fan but I know how tightly associated an anime aesthetic is with sexualized children. And a lot of people feel icky when it comes to that and I don't really blame them. The Persona series is one of my favorite things of all time and yet there's a ton of weird gross stuff in it. Sexualized teenagers, a romantic relationship with an adult teacher, etc. I guess I've just been numb to it since it's so prevalent in anime styled media.
Whereas Expedition 33 has adult characters who act like adults, which is kinda rare for this style of game. So in all, I don't really blame people for steering clear of anime aesthetic JRPGs yet enjoying games of a similar genre with adult characters. Also consider how Final Fantasy 7 is so beloved and also portrays adults (except Yuffie I guess).