When gaming, I hold the device in both hands, just as they depict in their marketing material:

When I'm on location and I have it sitting on the desk, I use the left joystick for scrolling and the right for moving the mouse, it works really well and I don't have to grip it (I configured AntiMicroX on Linux to translate the inbuilt Xbox controller to mouse movements).
It also has a builtin mouse mode, but you have to press the right trigger to speed up the mouse, so it's very unconvenient when you're not holding the device in your hands.