I’ve had NixOS absolutely refuse to run some compiler toolchain I depended upon that should’ve been dead simple on other distros, I’m really hesitant to try anything that tries to be too different anymore.
Yes, some toolchain expect you to run pre-compiled dynamically linked binaries. These won't work on NixOS, you need to either find a way to install the binary from nix and force the toolchain to use it or run patchelf on it somehow.