Xenoblade 3.
a world where each person only has only ten years to live and is forced to fight throughout in a never-ending war between two nations in a decaying land. There's a lot of depth surrounding the main characters, especially joint protagonist Mio who has only 3 months life remaining at the start of the story. Game gets real fucking dark.
And nah you don't need to play the first two to enjoy it, as long as you avoid the DLC expansion as that's the series conclusion.
Edit: also the most believable and well written romance between two characters I've ever seen in a game and the fantastic VA makes a huge impact (all UK talent - Mio's VA is better known for Peaky Blinders, Jenna Coleman is better known for Dr Who, for example). And anyone who says they didn't cry in chapter 5/6 is a liar.