I don't know. I never was much into modded Skyrim. The last time I played Skyrim was around 2012. Enderal installs like any other Steam game and comes with its own launcher. I only played Enderal because it was recommended to me since I really liked Gothic II and story focused games. I now also highly recommend it. This mod is better than at least 90% of games released in the last 10 years.

I use MO2 with quirks. I'm trying to remember what all I did, but I think I renamed MO2 to SkyrimLauncher.exe so steam would open MO2. Then I would launch Skyrim (skse) from there!

The quirks were you couldn't install inside of MO2 because it wouldn't connect to Nexus. The other thing was if I was installing a lot of mods or doing a lot of interactions in MO2 it would get slower and slower. Restarting it fixed that.

All that said I put a ton of hours into a 500ish mod game without issues!